I'm brand spankin' new to this biz, so I know nothing. However, I'm a big believer in following dreams such as this.
Off the bat, I'd say that finding an existing space that you can convert is how you keep this particular dream alive. Find the right type of space and you won't need a big remodel. Here's a look at a hugely popular one-screen joint that's just a mile or two from where I live:
www.flickr.com/photos/juneny/5178051977/...et-72157625270835309
This place is a converted school gym, complete with a flat floor, loveseats and sofas for seating, etc. But they do it right, and people love it. Please note, these folks did no remodel at all. They just weren't held back by anyone's idea of what type room can or cannot become a theatre. Find a place zoned for what you need and you can rule the world.
One thing to keep in mind - you'll hear from people
every day who tell you this can't be done. It's too expensive, there's not enough population, etc. But the experts will be all over the map on this stuff. Some will tell you it's a great idea while others will tell you it's impossible. Again, I know nothing and I may be on the brink of failure, but I'm about 3 weeks away from opening, and it's one of the best things I've ever done. Yes, I'm going digital, no it didn't break me and no I'm not using a VPF. If it's something you dream of doing, you give it a cold, hard look and you find a way to make it happen.